Really outside signaling

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Outside the guidelines, no salvation! Really?

Can a family physician practise good medicine without following clinical practice guidelines? Obviously, you have the right to come back with, “What do you mean by good medicine?” Let’s define it for our present purposes as that promoted by the 4 principles of family medicine: a family physician is a skilled clinician, family medicine is a community-based discipline, a family physician is a res...

متن کامل

Regulation of outside-in signaling and affinity

The adhesiveness of integrin L 2 is modulated by divalent cations. We mutated three metal ion-binding sites in the 2 I domain. The metal ion-dependent adhesion site (MIDAS) and the ligandinduced metal-binding site are required for ligand binding and sufficient for synergism between Ca2 and Mg2 . Adjacent to MIDAS (ADMIDAS) mutants are constitutively active but remain bent, with poor exposure of...

متن کامل

Notch signaling: Fringe really is a glycosyltransferase

Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch's developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch's glycosylation state.

متن کامل

Ubiquitylation within signaling pathways in- and outside of inflammation.

Ubiquitin is a highly conserved 76-amino-acid peptide that becomes covalently attached to lysine residues of target proteins. Since ubiquitin itself contains seven lysine residues, ubiquitin molecules can generate different types of polyubiquitin chains. Lys48-linked polyubiquitylation is well-known as posttranslational tag for targeting proteins for degradation by the 26S proteasome. Recent st...

متن کامل

Radiation-induced cell signaling: inside-out and outside-in.

Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen species. DNA damage causes activation of ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related protein, which induce cell cycle checkpoints and also modulate the activation of prosurvival and proapoptotic signalin...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2005

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1692rr5